Endocrine Abstracts

Background: Despite obligatory iodination of salt in the Czech Republic, pregnant women with higher demands on iodine intake may be at risk of iodine deficiency with potentially negative consequences for the course of pregnancy and foetal development. Determination of urinary iodine concentration (UIC) is a conventional but not widely available method used to estimate the iodine status. Based on previous studies, serum thyroglobulin (Tg) could serve as a more convenient marker...

Introduction: Cushing’s syndrome (CS) is a rare disease with incidence estimated 2-4 cases per million inhabitants per year. ACTH-dependent forms comprise up to 80% of all cases, of which 80% are central and 20% are ectopic, paraneoplastic forms of ACTH-dependent CS. Thymic neuroendocrine tumors (NET) are accounting for 0,4 - 3% of all NET’s with incidence of 0.02/100 000 inhabitants/year. Up to one third of them are hormonally active (secrete adrenocorticotropic hor...

Giant prolactinomas (GPs) are prolactin secreting pituitary adenomas (PitNETs) ≥4 cm, usually with prolactinaemia over 1000 mg/l and without co-secretion of other hormones. Aims: evaluation of long term treatment of GPs, the effect of D2 agonists and of different doses on prolactinaemia, tumour shrinkage and complications.Patients and methods: 33 patients (27 males, 82%) diagnosed with GP in our department between 1997 - 2020...